TABLE 2

Characterization of the hit compounds

Compound	Partition Coefficient LogP	Assays and Result Type
		FS-3			pNP-TMP
		IC₅₀	Mechanism of Inhibition	K_i	IC₅₀	Mechanism of Inhibition	K_i
		nM		nM	nM		nM
1	2.99	31.42	Competitive	12.98	N/A	N/A	N/A
2	3.54	6.50	Competitive	19.64	N/A	N/A	N/A
3	3.98	53.05	Competitive	7.14	314	Competitive	933

IC₅₀, concentration that inhibits the cleavage of LPC by 50%; K_i, inhibitory constant; N/A, not applicable due to lack of inhibition of pNP-TMP hydrolysis.