Compound | [35S]GTPγS Binding Inhibition IC50 ± S.E.M. | β-Arrestin Recruitment Inhibition IC50 ± S.E.M. | xCELLigencea IC50 ± S.E.M. |
---|---|---|---|
nM | |||
INCB3344 | 2.8 ± 0.8 | 3.2 ± 0.2 | 2.0 ± 0.5 |
BMS22 | 5.5 ± 1.8 | 4.8 ± 0.4 | 21 ± 6* |
RS504393 | 19 ± 7** | 68 ± 3 | 87 ± 15 |
Teijin | 183 ± 48 | 67 ± 13 | 292 ± 66* |
JNJ-27141491 | 3.9 ± 1.0** | 29 ± 1 | 25 ± 4 |
CCR2-RA-[R] | 24 ± 3 | 25 ± 4 | 64 ± 14*** |
↵a Inhibition of CCL2 was calculated from concentration-response curves derived from peak-analysis of CI changes.
↵* P < 0.05, versus β-arrestin data, analysis of variance (ANOVA), Tukey’s multiple comparison test; **P < 0.05, versus β-arrestin and xCELLigence data, ANOVA, Tukey’s multiple comparison test; ***P < 0.05, versus [35S]GTPγS and β-arrestin data, ANOVA, Tukey’s multiple comparison test.