pEC50 potency values of agonists at hFFA4 in various functional assays
| Assay | aLA | GW9508 | NCG21 | TUG-891 |
|---|---|---|---|---|
| Ca2+ | 5.25 ± 0.10 | 6.07 ± 0.08 | 5.21 ± 0.11 | 6.93 ± 0.07 |
| β-Arrestin-2 | 5.29 ± 0.05 | 6.04 ± 0.04 | 5.64 ± 0.03 | 7.19 ± 0.07 |
| β-Arrestin-1 | 4.86 ± 0.05 | 5.64 ± 0.04 | ND | 6.83 ± 0.06 |
| pERK | 4.08 ± 0.14 | 5.06 ± 0.25 | <4.5 | 5.83 ± 0.12 |
| Internalization | 4.76 ± 0.11 | 5.25 ± 0.10 | 5.51 ± 0.18 | 7.29 ± 0.12 |
ND, not determined.