TABLE 1

Effect of TNF-α, AP301, and AP318 on single-channel kinetics at E_h= −60 mV (n = 3–5)

Single-Channel Kinetic Parameters	Control	TNF-α	AP301	AP318
P_O	0.37 ± 0.03	0.77 ± 0.08^*	0.69 ± 0.05^*	0.78 ± 0.05^*
Mean open time (ms)	2.2 ± 0.9	23.5 ± 4.5^*	24.3 ± 4.8^*	26.5 ± 4.3^*
Number of bursts	993 ± 105	1274 ± 259**	2365 ± 419^*	1966 ± 402***
Events in burst	7.2 ± 1.7	46.3 ± 4.3^*	32.3 ± 5.0^*	16.1 ± 4.9***
Duration of burst (ms)	5.7 ± 1.3	210.6 ± 47.8^*	47.9 ± 1.4^*	42.2 ± 12.5^*
Mean intraburst interval (ms)	0.29 ± 0.03	0.60 ± 0.1***	0.63 ± 0.03^*	0.60 ± 0.12***