DMEs and transporters
Drug transporters are sometimes also categorized as phase 0 (influx) and phase III (efflux). Here we use the more general classification of phase III that includes all drug transporters.
| Gene Families | Additional Genes | ||
|---|---|---|---|
| Symbol | Full Name | Symbol | Full Name |
| Phase I | |||
| Adh | Alcohol dehydrogenase | Aadac | Arylacetamide deacetylase |
| Aldh | Aldehyde dehydrogenase | Cel | Carboxyl ester lipase |
| Aox | Alternative oxidase | Ddo | d-Aspartate oxidase |
| Cbr | Carbonyl reductase | Dpyd | Dihydropyrimidine dehydrogenase |
| Ces | Carboxylesterase | Dpys | Dihydropyrimidinase |
| Cyb5 | Cytochrome B5 | Gsr | Glutathione reductase |
| Cyp | Cytochrome P450 | Gusb | Glucuronidase |
| Dhrs | Dehydrogenase/reductase (SDR Family) Member | Hagh | Hydroxyacylglutathione hydrolase |
| Ephx | Epoxide hydrolase | Hprt | Hypoxanthine guanine phosphoribosyl transferase |
| Fmo | Flavin-containing monooxygenase | Xdh | Xanthine dehydrogenase |
| Gpx | Glutathione peroxidase | ||
| Hsd | Hydroxysteroid dehydrogenase | ||
| Mao | Monoamine oxidase | ||
| Pon | Paraoxonase | ||
| Uchl | Ubiquitin carboxyl-terminal esterase | ||
| Phase II | |||
| Acs | Acetyl-CoA synthetase | Aanat | Aralkylamine N-acetyltransferase |
| Agxt | Alanine-glyoxylate aminotransferase | As3mt | Arsenic (+3 oxidation state) methyltransferase |
| Akr | Aldo-keto reductase | Baat | Bile acid-CoA:amino acid N-acyltransferase |
| Alg | Asparagine-linked glycosylation | Ddost | Dolichyl-di-phosphooligosaccharide-protein glycotransferase |
| Ccbl | Cysteine conjugate-β lyase | Faah | Fatty acid amide hydrolase |
| Chst | Carbohydrate sulfotransferase | Gamt | Guanidinoacetate N-methyltransferase |
| Comt | Catechol-O-methyltransferase | Glyat | Glycine-N-acyltransferase |
| Galnt | Polypeptide-N-acetylgalactosaminyltransferase | Gnmt | Glycine-N-methyltransferase |
| Gcnt | Glucosaminyl (N-acetyl) transferase | Hnmt | Histamine-N-methyltransferase |
| Ggt | γ-Glutamyltransferase | Inmt | Indolethylamine-N-methyltransferase |
| Gst | Glutathionine S-transferase | Nnmt | Nicotinamide-N-methyltransferase |
| Mgat | Mannoside acetylglucosaminyltransferase | Pnmt | Phenylethanolamine-N-methyltransferase |
| Mgst | Microsomal glutathione S-transferase | Tpmt | Thiopurine-S-methyltransferase |
| Naa | N(α)-Acetyltransferase | ||
| Nat | N-Acetyltransferase | ||
| Nqo | NADPH dehydrogenase | ||
| Sat | Spermidine/spermine N1-acetyltransferase | ||
| Sulf | Sulfatase | ||
| Sult | Sulfotransferase | ||
| Ugt | UDP-glycosyltransferase | ||
| Phase III | |||
| Abcb | ATP-binding cassette transporter subfamily B (MDR/TAP) | ||
| Abcc | ATP-binding cassette transporter subfamily C (MRP) | ||
| Abcg | ATP-binding cassette transporter subfamily D (WHITE) | ||
| Slc10 | Solute Carrier Family 10 (sodium bile salt cotransport family) | ||
| Slc15 | Solute Carrier Family 15 (proton oligopeptide cotransporter family) | ||
| Slc21 | Solute Carrier Family 21 [organic anion transporter (SLCO) family] | ||
| Slc22 | Solute Carrier Family 22 (organic cation/anion/zwitterion transporter family) | ||
| Slc47 | Solute Carrier Family 47 [multidrug and toxin extrusion (MATE) family] | ||
| Slc51 | Solute Carrier Family 51 (transporters of steroid-derived molecules) | ||