Substrate for PNPHyor | Substrate for Human PNP | |
---|---|---|
Natural purine nucleosides | ||
Adenosine | + | − |
Inosine | + | + |
Guanosine | + | + |
2′-Deoxyadenosine | + | − |
2′-Deoxyinosine | + | + |
2′-Deoxyguanosine | + | + |
Xanthosine | − | + |
Purine nucleoside analogs | ||
2-Chloro-2′-deoxyadenosine (cladribine) | + | − |
2-Fluoroadenine-arabinofuranoside (fludarabine) | + | − |
2-Fluoro-2′-deoxyadenosine | + | − |
Methyl(talo)-F-Ado | + | − |
6-Methylpurine-2′-deoxyriboside (6-MeP-dR) | + | − |
6-Mercaptopurine riboside | + | + |
6-Thioguanosine | + | + |
8-Aminoguanosine | + | + |
5,6-Dichlorobenzimidazole ribofuranoside | + | + |
Adenine arabinofuranoside (araA) | + | − |
2-Amino-2′-deoxy-2′-fluoroadenosine | + | − |
Clofarabine | − | − |
Tubercidin | − | − |
7-Deaza-2′-deoxyadenosine | − | − |
3-Deaza-adenosine | − | − |
+, Substrate activity detected; −, no substrate activity detected.