TABLE 1

A number of antiasthma and antiallergenics act as potent agonists of human GPR35a

PathHunter human GPR35a–β-arrestin-2 interaction assays were performed using a CHO–K1 cell line stably expressing human GPR35 and β-arrestin-2. Data are presented as the mean ± S.E.M. and are derived from three independent experiments.

CompoundEC50
nM
Nedocromil sodium970 ± 87.0
Cromolyn disodium2980 ± 127
Bufrolin2.93 ± 0.71
Lodoxamide1.61 ± 0.42
Nivimedone sodium1930 ± 348
TranilastNo response