Parameter | Saline | ISO | AngII | |||
---|---|---|---|---|---|---|
WT | Tr | WT | Tr | WT | Tr | |
Mice (n) | 5 | 5 | 5 | 5 | 5 | 5 |
dP/dt max (mmHg/s) | 11,261 ± 938.35 | 11,376 ± 1171.89 | 7164 ± 777.67* | 10,104 ± 981.64** | 6941 ± 977.32* | 10,591 ± 1375.54*** |
dP/dt min (mmHg/s) | −8439 ± 1053.16 | −8739 ± 1025.11 | −4915 ± 782.48* | −6807 ± 690.78** | −4584 ± 554.01* | −6931.67 ± 577.32*** |
LVEDP (mmHg) | 4.68 ± 1.28 | 5.09 ± 1.39 | 12.83 ± 3.00* | 7.26 ± 1.36** | 12.78 ± 2.30* | 7.39 ± 1.51*** |
IVSd (mm) | 1.10 ± 0.22 | 1.05 ± 0.10 | 1.72 ± 0.13* | 1.17 ± 0.18** | 1.66 ± 0.54* | 1.10 ± 0.27 |
IVSs (mm) | 1.99 ± 0.13 | 1.59 ± 0.34 | 1.75 ± 0.25 | 1.92 ± 0.18 | 2.05 ± 0.38 | 1.49 ± 0.20 |
LVIDd (mm) | 2.87 ± 0.54 | 2.67 ± 0.30 | 3.42 ± 0.16 | 2.97 ± 0.34 | 3.71 ± 0.29 | 3.10 ± 0.71*** |
LVIDs (mm) | 1.07 ± 0.41 | 1.05 ± 0.34 | 2.23 ± 0.29* | 1.25 ± 0.37** | 2.77 ± 0.43* | 1.70 ± 0.39*** |
LVPWd (mm) | 1.10 ± 0.52 | 1.00 ± 0.40 | 1.65 ± 0.46 | 1.38 ± 0.34 | 1.74 ± 0.29 | 1.25 ± 0.35 |
LVPWs (mm) | 1.71 ± 0.80 | 1.33 ± 0.29 | 2.10 ± 0.36 | 1.90 ± 0.08 | 2.11 ± 0.58 | 1.46 ± 0.40 |
LVEF (%) | 90.55 ± 5.69 | 91.18 ± 3.98 | 63.29 ± 6.97* | 80.65 ± 6.19** | 61.87 ± 8.30* | 78.79 ± 6.28*** |
LVFS (%) | 68.19 ± 10.61 | 72.47 ± 12.26 | 41.28 ± 4.98* | 61.36 ± 13.37** | 40.99 ± 16.06* | 60.88 ± 7.49*** |
dP/dt max, maximal slope of systolic pressure increment; dP/dt min, diastolic pressure decrement; IVSd, interventricular septal thickness in diastole; IVSs, interventricular septal thickness in systole; LVEDP, left ventricular end diastolic pressure; LVEF, left ventricular ejection fraction; LVFS, left ventricular fractional shortening; LVIDd, left ventricular internal dimension in diastole; LVIDs, left ventricular internal dimension in systole; LVPWd, left ventricular posterior wall thickness in diastole; LVPWs, left ventricular posterior wall thickness in systole.
↵* P < 0.05 versus WT mice treated with saline; **P<0.05 versus WT mice treated with ISO; ***P<0.05 versus WT mice treated with AngII.