Operational Parameters | Kinetic Parameters | |||||
---|---|---|---|---|---|---|
Log(KA) Mean ± S.E.M. | Log(τ) Mean ± S.E.M. | Log (τ/KA) Mean ± S.E.M. | Plateau Internalization Mean ± S.E.M. | t1/2 (min) mean ± S.E.M. | ||
Deltorphin II (n = 12) | −7.98 ± 0.13 | 0.57 ± 0.06 | 8.56 ± 0.14a | Deltorphin II (n = 9) | 67 ± 2** | 15 ± 2 |
Met-enkephalin (n = 11) | −6.58 ± 0.11 | 0.35 ± 0.05 | 6.93 ± 0.12b | Met-enkephalin (n = 7) | 63 ± 3** | 13 ± 2 |
DPDPE (n = 9) | −6.10 ± 0.36 | 0.58 ± 0.56 | 6.68 ± 0.67 | DPDPE (n = 8) | 63 ± 2** | 15 ± 2 |
SNC-80 (n = 9) | −4.39 ± 0.17 | 0.87 ± 0.13 | 5.27 ± 0.22 | SNC-80 (n = 5) | 66 ± 2** | 15 ± 2 |
Morphine (n = 10) | N/A | N/A | N/A | Morphine (n = 3) | N/A | N/A |
mcp-TIPP (n = 8) | N/A | N/A | N/A | mcp-TIPP (n = 3) | 9 ± 2* | 21 ± 6 |
SB235863 (n = 10) | N/A | N/A | N/A | SB235863 (n = 3) | N/A | N/A |
N/A, not applicable.
↵a Deltorphin II versus met-enkephalin, P < 0.05.
↵b Met-enkephalin versus SNC-80, P < 0.05.
↵* For each time course in Fig. 3B, maximal internalization observed at 90 minutes was compared with internalization observed at 5 minutes by mean of student’s t test; **P < 0.001; *P < 0.05.