β2 Ligand | koff | kon | pKd | pKi |
---|---|---|---|---|
min−1 | ΜM−1 min−1 | |||
Bisoprolol | 6.86 ± 2.09 | 4.61 ± 1.30 × 107 | 6.83 ± 0.02 | 6.79 ± 0.05 |
Atenolol | 1.27 ± 0.31 | 4.57 ± 0.73 × 106 | 6.58 ± 0.06 | 6.29 ± 0.05 |
Labetalol | 1.22 ± 0.08 | 2.03 ± 0.33 × 108 | 8.20 ± 0.08 | 8.45 ± 0.18 |
Metoprolol | 5.27 ± 0.82 | 4.39 ± 0.92 × 107 | 6.90 ± 0.06 | 6.75 ± 0.02 |
Bucindolol | 0.039 ± 0.007 | 1.39 ± 0.16 × 109 | 10.56 ± 0.03 | 10.52 ± 0.03 |
Carvedilol | 0.033 ± 0.006 | 1.85 ± 0.13 × 109 | 10.77 ± 0.13 | 10.88 ± 0.08 |
Propranolol | 0.46 ± 0.05 | 3.65 ± 0.42 × 109 | 9.90 ± 0.03 | 9.76 ± 0.03 |
Salmeterol | 1.16 ± 0.16 | 3.50 ± 0.57 × 109 | 9.47 ± 0.01 | 9.49 ± 0.04 |
ICI 118,551 | 0.21 ± 0.03 | 7.63 ± 0.84 × 108 | 9.56 ± 0.03 | 9.36 ± 0.14 |
Sotalol | 3.10 ± 0.67 | 2.29 ± 0.46 × 107 | 6.87 ± 0.02 | 6.66 ± 0.09 |
Nadolol | 0.14 ± 0.04 | 1.01 ± 0.33 × 108 | 8.87 ± 0.01 | 8.82 ± 0.05 |
Formoterol | 3.00 ± 0.38 | 1.78 ± 0.21 × 108 | 7.77 ± 0.01 | 7.28 ± 0.10a |
Timolol | 0.033 ± 0.003 | 3.76 ± 0.23 × 108 | 10.06 ± 0.04 | 9.90 ± 0.03 |
Cyanopindolol | 0.002 ± 0.001 | 1.83 ± 0.15 × 109 | 12.04 ± 0.18 | 11.74 ± 0.42 |
CGP12177 | 0.048 ± 0.004 | 2.89 ± 0.34 × 108 | 9.78 ± 0.02 | 9.67 ± 0.09 |
Isoprenalinea | 3.06 ± 1.53 | 2.47 ± 1.39 × 107 | 6.89 ± 0.08 | 6.73 ± 0.15 |
Salbutamola | 4.06 ± 1.19 | 2.05 ± 1.03 × 107 | 6.65 ± 0.14 | 6.54 ± 0.07 |
↵a Data from Sykes and Charlton (2012).