Effect of Gβ5-RGS7 on carbachol- and pilocarpine-stimulated Ca2+ responses
Values are the mean ± S.E.M.
| Compound | M3R | M3R + Gβ5-RGS7 | ||||
|---|---|---|---|---|---|---|
| n | Emax | −logEC50 | n | Emax | −logEC50 | |
| Carbachol | 17 | 100 ± 6 | 5.5 ± 0.17 | 19 | 56 ± 3 | 5.4 ± 0.13 |
| Pilocarpine | 15 | 100 ± 5 | 5.6 ± 0.10 | 18 | 37 ± 3 | 5.8 ± 0.19 |
Emax, maximum amplitude of 340/380 ratio in percentage of M3R (= 100%); −logEC50 [M], negative logarithm of agonist concentration for half-maximum effect concentration–response curve; n = number of coverslips.