Growth inhibition induced by Hsp90 inhibitors in human breast cancer cell lines dependent upon NQO1 activity
Data expressed as mean ± S.D. of three independent experiments.
| Compound | IC50 | IC50-Fold Difference | |
|---|---|---|---|
| MDA468 | MDA468/NQ16 | ||
| µM | |||
| GA | 0.06 ± 0.01 | 0.02 ± 0.01 | 3 |
| 19Ph-GA | 7.45 ± 0.51 | 1.19 ± 0.08 | 6 |
| 17-AAG | 10.05 ± 1.07 | 0.86 ± 0.16 | 11 |
| 19Ph-AAG | 88.37 ± 2.46 | 38.79 ± 10.90 | 2 |
| 17-DMAG | 0.61 ± 0.02 | 0.19 ± 0.02 | 3 |
| 19Ph-DMAG | 16.48 ± 2.14 | 3.28 ± 0.26 | 5 |