UGT | Substrate | Vmax | Km(Ks) | Ki | Vi | n | CLint(CLmax) | R2 |
---|---|---|---|---|---|---|---|---|
pmol/min/mg | μM | pmol/min/mg | μl/min/mg | |||||
1A1 | 4-NPa | 489.8 ± 71.6 | 2428 ± 542.9 | 6784 ± 1852 | 0.20 | 0.9727 | ||
1-Naphthola | 460.0 ± 93.6 | 159.8 ± 58.5 | 1845 ± 1229 | 2.88 | 0.9779 | |||
BPAa | 26.4 ± 2.3 | 106.7 ± 15.8 | 510.9 ± 102.9 | 0.25 | 0.9832 | |||
MPAa | 332.1 ± 14.3 | 334.3 ± 26.0 | 6573 ± 1162 | 0.99 | 0.9985 | |||
Diclofenaca | 170.6 ± 6.8 | 901.8 ± 64.0 | 11,051 ± 1532 | 0.19 | 0.9992 | |||
1A7 | 4-MUa | 855.2 ± 74.1 | 142.4 ± 22.2 | 2835 ± 1056 | 6.01 | 0.9941 | ||
4-NPa | 471.2 ± 46.0 | 764.5 ± 116.8 | 2733 ± 509.4 | 0.62 | 0.9958 | |||
1B1 | 4-MUa | 250.0 ± 20.3 | 17.7 ± 2.46 | 94.8 ± 15.3 | 14.1 | 0.9833 | ||
4-NPb | 659.6 ± 43.4 | 281.9 ± 28.4 | 1931 ± 182.8 | 128.3 ± 10.3 | 1.75 ± 0.16 | 1.18 | 0.9959 | |
1-Naphthola | 88.3 ± 5.6 | 47.6 ± 4.5 | 243.0 ± 40.4 | 1.86 | 0.9910 | |||
MPAa | 225.7 ± 22.5 | 60.9 ± 12.5 | 594.8 ± 135.7 | 3.71 | 0.9631 | |||
E2a,c | 8.82 ± 0.77 | 93.6 ± 14.4 | 1146 ± 352.1 | 0.094 | 0.9957 | |||
5A5 | 1-Naphtholb | 12.7 ± 5.2 | 5316 ± 2786 | 1655 ± 612.7 | 0.78 ± 0.11 | 1.11 ± 0.08 | 0.0017 | 0.9987 |
t-OPd | 2.80 ± 0.057 | 334.0 ± 16.1 | 0.0084 | 0.9992 | ||||
5B2 | t-OPa | 429.7 ± 76.2 | 859.3 ± 179.4 | 389.4 ± 97.0 | 0.50 | 0.9986 | ||
5E1 | E2a,c | 89.8 ± 1.5 | 13.4 ± 0.62 | 2579 ± 647.7 | 6.70 | 0.9988 | ||
Testosteronea | 477.1 ± 13.7 | 30.6 ± 2.7 | 3422 ± 608.9 | 15.6 | 0.9936 |