The relative LC/MS peak areas for b-AP15 and its metabolites in mouse and human hepatocytes
The quantification is based in the assumption of identical LC/MS response between all compounds.
| Metabolite | Mouse Hepatocytes | Human Hepatocytes |
|---|---|---|
| % area | ||
| Parent | 2.7 | 5.0 |
| M1 | 0.5 | 3.6 |
| M2 | 0.5 | 2.5 |
| M3 | 0.2 | 1.3 |
| M4 | 7.8 | 5.5 |
| M5 | 11.4 | 4.8 |
| M6 | 23.2 | 21.1 |
| M7 | 6.5 | 0.4 |
| M8 | 1.1 | 2.5 |
| M9 | 10.0 | 2.0 |
| M10 | 8.6 | — |
| M11 | 6.5 | — |
| M12 | 6.8 | — |
| M13 | 1.3 | 3.7 |
| M14 | 1.5 | 0.5 |
| M15 | 2.8 | — |
| M16 | 5.0 | 0.7 |
| M17 | 3.7 | 0.6 |
| M18 | — | 3.9 |
| M19 | — | 1.6 |
| M20 | — | 5.4 |
| M21 | — | 11.0 |
| M22 | — | 4.9 |
| M23 | — | 19.2 |
—, metabolites were not detected in these species.