Defining the allosteric binding site by displacing [3H]LY2119620 with other allosteric compounds in the presence of 100 μM oxotremorine-M
Displacement of [3H]LY2119620 by other allosteric compounds in the presence of 100 μM oxotremorine-M. The Ki values shown are the result of three independent experiments performed in duplicate. Values are expressed as the averages ± S.E.M.
| Receptor Subtype | LY2119620 | LY2033298 | VU10010 | VU152100 | Gallamine | WIN 62,577 |
|---|---|---|---|---|---|---|
| M2 | 15.3 ± 1.36 | 87.1 ± 20.9 | >10,000 | >10,000 | >10,000 | >10,000 |
| M4 | 1.03 ± 0.0776 | 2.14 ± 0.279 | 42.6 ± 16.4 | 48.3 ± 10.7 | >10,000 | >10,000 |