Genotypes of human, chimpanzee, and macaque β3-adrenoceptors
The mutation and position of the 5 single nucleotide polymorphisms are depicted in columns 1 and 2, respectively. T190C is the Trp64Arg mutation. Δtg3273/3274 refers to the repeat polymorphism, where the nine repeats in wild type are reduced to eight in the polymorphic human gene. Based upon data from Michel et al. (2008), Vrydag et al. (2009), and Teitsma et al. (2013).
| Polymorphism | Position | Wild Type | ||
|---|---|---|---|---|
| Human | Chimpanzee | Macaque | ||
| T190C | Coding | T | C | C |
| g1219t | Intron | g | g | g |
| a2135g | Intron | a | a | a |
| g25002c | 3′-UTR | g | c | c |
| a3558t | 3′-UTR | a | t | t |
| Δtg3273/32744 | 3′-UTR | — | — | — |
UTR, untranslated region.