Effect of PDE inhibitors on the potency of formoterol in driving gene expression in the absence and presence of dexamethasone
pEC50 values for the potency of formoterol at inducing gene expression in the absence or presence of siguazodan (10 mM) plus rolipram (10 mM) (Sig + Roli) or with dexamethasone (1 mM) in the absence or presence of siguazodan plus rolipram are derived from the data shown in Figs. 6B and 9B, respectively. Data are presented as the mean ± S.E. unless otherwise indicated.
| Gene | Treatment | Potency to Formoterol (pEC50) | Determinations | Potency to Formoterol in the Presence of 1 µM Dexamethasone (pEC50) | Determinations |
|---|---|---|---|---|---|
| M | n | M | n | ||
| RGS2 | Naïve | 10.8 ± 0.4 | 6 | 10.9 ± 0.1 | 5 |
| + Sig + Roli | 11.8 ± 0.3 | 6 | 11.9 ± 0.2 | 5 | |
| CD200 | Naïve | 10.9 ± 0.1 | 6 | 10.9 ± 0.1 | 5 |
| + Sig + Roli | 11.8 ± 0.2 | 6 | 12.0 ± 0.1 | 5 | |
| CRISPLD2 | Naïve | 10.7 ± 0.2 | 6 | 11.0 ± 0.1 | 5 |
| + Sig + Roli | 11.6 ± 0.2 | 6 | 11.9 ± 0.3 | 5 |