LDK1203 and LDK1222 binding to the wild-type CB1 receptor
| Kia | |
|---|---|
| nM | |
| Versus [3H]CP55,940 | |
| CP55,940 | 2.56 (1.45–4.51)b |
| LDK1203 | 260 (80.7–837) |
| LDK1222 | 331 (177–619) |
| Versus [3H]SR141716A | |
| SR141716A | 5.23 (3.29–8.32)b |
| LDK1203 | 297 (192–458) |
| LDK1222 | 366 (144–928) |
↵a Data are the median and corresponding 95% confidence limits of three independent experiments performed in duplicate. Ki values were determined from competition binding assays using [3H]CP55,940 or [3H]SR141716A as tracers at their respective Kd values, as described in Results.
↵b Binding values are from Ahn et al. (2009) for comparison.