Evaluation of CD-160130 toxicity in healthy human bone marrow colonies.
Results of the overall colony numbers obtained with clonogenic assay of three samples of healthy bone marrow treated with two different concentrations of CD-160130 (5 and 10 μM) are reported. The different colony fractions (CFU-GEMM, CFU-GM, CFU-G, CFU-M, CFU-E and BFU-E) for each group are reported. All the data were average ± S.E.M.
| Total CFU Number | CFU-GEMM Fraction | CFU-GM Fraction | CFU-G Fraction | CFU-M Fraction | BFU-E Fraction | CFU-E Fraction | |
|---|---|---|---|---|---|---|---|
| % | % | % | % | % | % | % | |
| Control | 100 | 5 ± 1 | 19.5 ± 2.5 | 15 ± 3 | 31 ± 3 | 7 ± 1 | 22.5 ± 1.5 |
| CD-160130 (5 µM) | 97 ± 5.2 | 5.5 ± 1.5 | 21.5 ± 2.5 | 14 ± 3 | 28.5 ± 2.5 | 6.5 ± 0.5 | 24 ± 2 |
| CD-160130 (10 µM) | 75 ± 8.8 | 4 ± 1 | 18 ± 1 | 13 ± 3 | 25 ± 1 | 9 ± 0 | 31 ± 1 |
BFU, burst forming unit.