Effect of CD-160130 on viability of normal and solid tumor cell lines.
Data gathered with CD-160130 on two normal cell lines (PBMNC and EBV-infected B-lymphocytes) and on a tumour cell line (HCT116) are reported, together with the KCNH2b gene expression. A direct comparison between the expression of the two transcripts (KCNH2a and KCNH2b) was not feasible, because of the different sensitivity of the primers used to detect the two transcripts. All the data were the average ± S.E.M.
| PS / Cell line | 1B gene expression (arbitrary units) | Mean ED50 (±SEM) of CD-160130 |
|---|---|---|
| PBMNC | 0 (1A: 0) | 37% maximum killing at 10 μM |
| EBV-infected B lymphocytes | 0 (1A: 0) | 17% maximum killing at 10 μM |
| HCT116 | 0 (1A: 62.4) (Crociani et al., 2013) | 11.94 ± 0.92 μM |
EBV, Epstein-Barr Virus; 1A, KCNH2a.