TABLE 1

Inhibitory efficacy of mono- and difluorobenzoates on hKCa3.1

Data are derived from inside-out patch-clamp experiments on hKCa3.1 stably expressed in HEK293 cells. Data are given as mean ± S.E.M., n ≥ 3.

CompoundIC50Control at 1 μMControl at 5 μMControl at 10 μM
%
4-Amino-3-fluorobenzoic acidNTNT90 ± 3
4-Hydroxy-3-fluorobenzoic acidNTNT80 ± 8
1,3-PhenylenedimethanolNTNT106 ± 8
RA-194 ± 187 ± 2NT
RA-217 ± 3 nM4 ± 1NTNT
RA-36 ± 2 nM12 ± 22 ± 1NT
RA-415 ± 6NTNT
RA-597 ± 294 ± 1NT
RA-683 ± 374 ± 11NT

  • NT, not tested.