Summary data
Summary electrophysiological data for ion channels analyzed in this study. Brackets in numbers represent the number of cells tested for a particular measurement. Statistically significant differences are indicated in comparison with ASIC2a.
| Chimera | Mean Peak Current Density + S.E.M. at pH 4 | Mean τ + S.E.M. at pH 4 | EC50 | IC50 | Hill Coefficient EC/IC | Reversal + S.E.M. |
|---|---|---|---|---|---|---|
| pA/pF (n) | ms (n) | pH (n) | mV (n) | |||
| ASIC2a | 421 ± 57 (50) | 1275 ± 111 (17) | 4.44 (19) | 6.13 (9) | 0.88/1.46 | 31.4 (9) |
| AB5 | 924 ± 156 (26)* | 1471 ± 150 (12) | 4.48 (14) | 6.34 (7)* | 0.83/1.73 | 33.5 (7) |
| AB4.1 | 43 ± 14 (11)**** | 1336 ± 141 (9) | 4.13 (6)** | — | 0.84 | — |
| AB11-5 | 23 ± 7 (8)**** | 1150 ± 89 (5) | — | — | — | — |
| AB6 | 560 ± 160 (20) | 1637 ± 150 (9)* | 4.1 (13)**** | 6.44 (6)**** | 0.8/1.86 | 39.2 (6) |
| AB5-N | 499 ± 203 (15)* | 561 ± 74 (8)** | — | — | — | — |
—, data not collected.
↵* P < 0.05; ** P < 0.005; **** P < 0.0001.