EC50 for ACh dose-response curves on α9 and α10 mutants that affected α-CTx RgIA potency
Values are mean ± S.E.M. from at least three different oocytes.
| nAChR | ACh EC50 (95% CI) μM | Hill Slope |
|---|---|---|
| α9α10 | 10.1 (8.68–11.8) | 1.2 ± 0.1 |
| α9T61Iα10 | 10.7 (8.90–12.9) | 1.4 ± 0.2 |
| α9D121Lα10 | 323 (238–437) | 1.8 ± 0.4 |
| α9α10E197Q | 193 (145–257) | 0.54 ± 0.04 |
| α9α10P200Q | 419 (369–477) | 0.81 ± 0.04 |