nAChR Mutation | IC50 (nM) RgIA (95% CI) | Hill Coefficient |
---|---|---|
α9α10 | 1.49 (1.13–1.95) | 1.24 ± 0.19 |
α9T61Iα10a | 2610 (1230–5330)a | 0.71 ± 0.16 |
α9T61Eα10a | 28.6 (17.1–47.6)a | 0.51 ± 0.06 |
α9D121Lα10a | >1000a | ND |
α9E197Qα10 | 1.15 (0.77–1.73) | 0.61 ± 0.07 |
α9P200Qα10 | 2.72 (2.13–3.46) | 0.99 ± 0.09 |
α9D201Nα10 | 2.61 (2.08–3.26) | 0.89 ± 0.07 |
ND, not determined.
↵a Mutations making the greatest difference in toxin potency.