Neurotransmitter- and receptor-mediated G protein modulation of Cav2 channels
| Neurotransmitter | Receptor | Cav Channel | Tissue/Species | Reference |
|---|---|---|---|---|
| Ach | M4 | Cav2.2 | SCG/rat | Bernheim et al., 1991 |
| M2 | Cav2.1 and Cav2.2 | SCG/mouse | Shapiro et al., 1999 | |
| Adenosine | A1 | Cav2.2 | Ciliary ganglion/chicken | Yawo and Chuhma, 1993 |
| Cav2.2 | DRG/chicken | Kasai and Aosaki, 1989 | ||
| Cav2.1 and Cav2.2 | Cerebellum/rat | Dittman and Regehr, 1996 | ||
| Cav2.2 and Cav2.3 | Hippocampus (CA3→CA1)/rat | Wu and Saggau, 1994 | ||
| ATP/ADP | P2Y | Cav2.2 | SCG/rat | Brown et al., 2000; Filippov et al., 2000a |
| Dopamine | D2 | HVA | DRG/chicken | Marchetti et al., 1986 |
| Endocannabinoids | CB1 | Cav2.1 | SCG/rat | Garcia et al., 1998a |
| Cav2.1, Cav2.2, and Cav2.3 | Cerebellum | Brown and Russell, 2004 | ||
| GABA | GABA B | Cav2.1 and Cav2.2 | DRG/rat | Dolphin and Scott, 1987 |
| DRG/chicken | Deisz and Lux, 1985; Grassi and Lux, 1989 | |||
| Cerebellum/rat | Dittman and Regehr, 1996 | |||
| Cav2.2 and Cav2.3 | Hippocampus (CA3→CA1)/guinea pig | Wu and Saggau, 1995 | ||
| Cav2.2 | SCG/rat | Filippov et al., 2000b | ||
| Galanin | GalR1 | Cav2.2 | Hypothalamus/rat | Simen et al., 2001 |
| Glutamate | mGluR1 | Cav2.2 | SCG/rat | Kammermeier and Ikeda, 1999 |
| LHRH | LHRH-R | Cav2.2 | SCG/bullfrog | Elmslie et al., 1990; Boland and Bean, 1993; Kuo and Bean, 1993 |
| Noradrenaline | α2-Adrénergique | Cav2.2 | SCG/bullfrog | Bean, 1989 |
| Cav2.2 | SCG/rat | Garcia et al., 1998b | ||
| Non-L | NG108-15 | Docherty and McFadzean, 1989; McFadzean and Docherty, 1989 | ||
| NPY | Y2 | Non-L | SCG/rat | Plummer et al., 1991 |
| Cav2.2 | SCG/rat | Toth et al., 1993 | ||
| Opioids - Enkephalins | μ | Cav2.2 | NG108-15 | Kasai, 1992 |
| Opioids - Dynorphins | κ | Non-L | DRG/rat | Bean, 1989 |
| Serotonin | 5HT-1A | Non-L | Spinal neuron/Lamprey | Hill et al., 2003 |
| Somatostatin | SS-R | Cav2.2 | DRG/rat | Ikeda and Schofield, 1989b |
| SCG/rat | Ikeda and Schofield, 1989a | |||
| Substance P | NK1 | Cav2.2 | SCG/rat | Shapiro and Hille, 1993 |
| VIP | VIP-R | Cav2.2 | SCG/rat | Zhu and Ikeda, 1994 |
Ach, acetylcholine; LHRH, luteinizing hormone-releasing hormone; NPY, neuropeptide Y; SCG, superior cervical ganglion; VIP, vasoactive intestinal peptide.