TABLE 1

pKi values from standard fit

CompoundpKi-GTP coupling (95% CI)pKi-βarr2 recruitment (95% CI)
6′-GNTI8.9 (9.1 to 8.6)8.1 (8.8 to 7.3)
Nalbuphine7.0 (7.3 to 6.7)6.6 (6.7 to 6.5)
Nalmefene8.7 (9.5 to 7.9)8.1 (8.2 to 8.0)