TABLE 4

LogRA values from the competitive fit

CompoundLogRAGTP coupling (95% CI)LogRAβarr2 recruitment (95% CI)
U69,59300
6′-GNTI1.2 (0.8 to 1.6)0.6 (0.4 to 0.9)
Nalbuphine−1.0 (−1.4 to −0.7)−0.9 (−1.1 to −0.7)
Nalmefene0.8 (0.6 to 0.9)0.3 (0.1 to 0.5)