Gene ontology enrichment of genes downregulated by COH29 treatment
| Comparison | COH29 effect in BRCA1-deficient cells | COH29 effect in BRCA1 wild-type cells | BRCA1 wild-type vs. BRCA1 deficient cells |
|---|---|---|---|
| Treatment groups | HCC1937-COH29 vs. HC1937 | HCC1937 + BRCA1-COH29 vs. HC1937 + BRCA1 | HCC1937 + BRCA1-COH29 versus HCC1937-COH29 |
| DNA repair, P | 0.018 | 1.6 × 10−5 | 0.001 |
| DNA ligation involved in DNA repair, P | 0.00065 | 0.0066 | 0.06 |
| Double-strand break repair via nonhomologous end joining, P | 0.049 | 0.041 | 0.04 |
| Double-strand break repair via homologous recombination, P | 0.0069 | 0.0046 | 0.26 |
| Double-strand break repair, P | 0.0015 | 6.9 × 10−5 | 0.3 |