Pharmacokinetic parameters of quinidine, etoposide, and acetaminophen following a single oral administration to monkeys at 9:00 or 21:00
Each value represents the mean ± S.E.
| Compound | Cmax | AUC Ratio | t1/2 Ratio | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 9:00 | 21:00 | Cmax Ratio 9:00/21:00 | 9:00 | 21:00 | AUC Ratio 9:00/21:00 | 9:00 | 21:00 | t1/2 Ratio 9:00/21:00 | |
| nM | nM × hour | hours | |||||||
| Quinidine | 90.5 ± 63 | 53.5 ± 41 | 2.16 ± 0.551 | 241 ± 170 | 182 ± 134 | 1.43 ± 0.108a | 1.34 ± 0.296 | 2.62 ± 0.382 | 0.528 ± 0.116 |
| Etoposide | 707 ± 195 | 367 ± 81 | 1.94 ± 0.266 | 1860 ± 494 | 1640 ± 346 | 1.14 ± 0.167 | 2.34 ± 0.459 | 3.35 ± 0.337 | 0.714 ± 0.162 |
| Acetaminophen | 9030 ± 1890 | 9490 ± 607 | 0.956 ± 0.192 | 19,900 ± 3690 | 22,300 ± 3000 | 0.882 ± 0.0486 | 1.57 ± 0.0870 | 1.85 ± 0.250 | 0.884 ± 0.154 |
↵a Significantly different from the value of acetaminophen AUC ratio by Student’s t test; P < 0.05.