Ligand | Logα′a [α′] | pKBb | pKic | Bmaxd |
---|---|---|---|---|
CP55940 | 0.5 ± 1.0 [3.2] | 5.4 ± 0.1 | 6.8 ± 0.6 | 391 ± 11.1 |
HU-210 | 0.0 ± 0.7 [1.0] | 5.6 ± 0.1 | 7.0 ± 0.3 | 393 ± 15.3 |
WIN55,212-2 | 0.6 ± 0.5 [4.0] | 5.2 ± 0.1 | 5.8 ± 0.2 | 427 ± 16.8 |
Δ9-THC | 0.3 ± 0.2 [2.0] | 5.6 ± 0.1 | 6.7 ± 0.1 | 393 ± 16.2 |
Methanandamide | 0.3 ± 0.6 [2.0] | 5.4 ± 0.1 | 5.5 ± 0.2 | 405 ± 12.4 |
Anandamide | 0.3 ± 0.4 [2.0] | 5.4 ± 0.0 | 5.2 ± 0.1 | 411 ± 8.02 |
2-AG | 0.5 ± 0.2 [3.2] | 5.4 ± 0.1 | 5.9 ± 0.6 | 399 ± 9.88 |
↵a Logarithm of the binding cooperativity factor between Org27569 and cannabinoid agonists.
↵b The negative logarithm of the allosteric modulator dissociation constant.
↵c The negative logarithm of the competing orthosteric ligand dissociation constant.
↵d The maximum number of [3H]SR141716A binding sites expressed as percentage of specific binding.