Ligand | cAMP | pERK1/2 | cAMP/pERK1/2 | |||
---|---|---|---|---|---|---|
LogR | ΔLogR | LogR | ΔLogR | ΔΔLogR | BF | |
CP55940 | 8.3 ± 0.2 | 2.6 ± 0.2 | 7.9 ± 0.1 | 2.0 ± 0.1 | 0.6 ± 0.2 | 3.9 |
HU-210 | 8.8 ± 0.2 | 3.1 ± 0.2 | 7.6 ± 0.1 | 1.8 ± 0.1 | 1.3 ± 0.2* | 20.8 |
WIN55,212-2 | 6.9 ± 0.2 | 1.2 ± 0.2 | 6.8 ± 0.1 | 1.0 ± 0.1 | 0.2 ± 0.2 | 1.7 |
Δ9-THC | 7.1 ± 0.3 | 1.4 ± 0.3 | 6.5 ± 0.2 | 0.6 ± 0.2 | 0.8 ± 0.4 | 5.6 |
Methanandamide | 6.9 ± 0.2 | 1.2 ± 0.2 | 5.9 ± 0.2 | 0.0 ± 0.2 | 1.2 ± 0.3* | 15.1 |
Anandamide | 6.3 ± 0.2 | 0.6 ± 0.2 | 5.6 ± 0.1 | −0.3 ± 0.1 | 0.8 ± 0.2 | 6.8 |
2-AG | 5.7 ± 0.2 | 0.0 ± 0.2 | 5.9 ± 0.1 | 0.0 ± 0.1 | 0.0 ± 0.2 | 1.0 |
↵* P < 0.05, one-way analysis of variance with Bonferroni’s multiple comparison test between ΔΔLogR for 2-AG compared with other cannabinoids.