Hidden Markov maximum interval likelihood fitting of the steady-state currents
Idealized current records were fitted to the gating scheme as described in Fig. 7. All rates have units of s−1. Data are mean ± S.E.M. from patches containing one active channel fitted individually. The rates were compared by unpaired t test.
| Rates | 0 Calcium | 0.5 Calcium | ||
|---|---|---|---|---|
| Control (n = 9) | PS (n = 5) | Control (n = 5) | PS (n = 6) | |
| s−1 | ||||
| C1→C2 | 95 ± 5 | 160 ± 20** | 115 ± 30 | 85 ± 15 |
| C2→C1 | 45 ± 5 | 140 ± 40** | 50 ± 15 | 35 ± 5 |
| C2→C3 | 260 ± 10 | 485 ± 120* | 230 ± 35 | 180 ± 15 |
| C3→C2 | 865 ± 90 | 825 ± 190 | 830 ± 220 | 410 ± 40 |
| C3→O1 | 735 ± 60 | 860 ± 140 | 825 ± 115 | 640 ± 75 |
| O1→C3 | 1665 ± 150 | 630 ± 80*** | 1280 ± 135 | 2130 ± 220** |
| O1→O2 | 1230 ± 340 | 825 ± 515 | 920 ± 230 | 70 ± 30** |
| O2→O1 | 1655 ± 280 | 885 ± 230 | 1745 ± 480 | 815 ± 290 |
| C1→D1 | 2.1 ± 0.4 | 1.4 ± 0.3 | 3.0 ± 1.4 | 1.7 ± 0.5 |
| D1→C1 | 1.3 ± 0.3 | 0.4 ± 0.1 | 0.8 ± 0.2 | 0.7 ± 0.2 |
| C2→D2 | 4.6 ± 1.2 | 11.3 ± 4.4 | 8.4 ± 1.9 | 5.5 ± 2.0 |
| D2→C2 | 15.8 ± 1.5 | 25.7 ± 6.3 | 18.0 ± 4.2 | 15.6 ± 4.0 |
↵* P < 0.05; **P < 0.01; *** P < 0.001.