TABLE 1

Serum biochemical parameters of control (saline treated) and mice treated with DMA with single bolus oral administration at increasing dose of 300, 500, 750, 1500, and 2000 mg/kg bw

Values are expressed as mean ± S.D. with n = 4 for control and treatment groups. Statistical analysis was performed by Student t test. P ≤ 0.05 was considered statistically significant. Samples were analyzed in triplicate.

Biochemical Parameters	Dose
Biochemical Parameters	Control	300	500	750	1500	2000
	mg/kg bw
Total protein (g/dl)	5.01 ± 1.07	4.41 ± 0.07	5.51 ± 1.87	5.55 ± 0.31	5.75 ± 0.34	5.48 ± 0.37
Albumin (g/dl)	2.67 ± 0.32	2.96 ± 0.22	2.87 ± 0.39	2.53 ± 0.08	2.59 ± 0.1	2.69 ± 0.18
Cholesterol (mg/dl)	109.21 ± 16.4	86.75 ± 10.28	97.13 ± 8.99	92.09 ± 13.6	93.28 ± 16.4	82.79 ± 18.4
Triglyceride (mg/dl)	115.89 ± 23.29	105.89 ± 23.2	120.58 ± 33.1	79.56 ± 26.9	71.42 ± 16.3	94.38 ± 17.1
Urea (mg/dl)	20.19 ± 4.71	19.83 ± 0.33	28.50 ± 3.25	29.76 ± 5.24	37.15 ± 5.33	32.22 ± 6.8
Blood urea nitrogen (mg/dl)	9.41 ± 2.17	9.26 ± 0.15	13.20 ± 1.52	13.71 ± 2.71	12.34 ± 2.87	15.09 ± 3.2
Uric acid (mg/dl)	2.19 ± 0.30	2.8 ± 0.98	2.18 ± 0.32	2.88 ± 0.70	2.36 ± 0.24	1.99 ± 1.03
Creatinine (mg/dl)	1.90 ± 0.36	1.96 ± 0.18	2.20 ± 0.29	2.24 ± 0.60	1.90 ± 0.17	1.79 ± 0.14
Total bilirubin (mg/dl)	0.25 ± 0.33	0.23 ± 0.03	0.28 ± 0.18	0.22 ± 0.19	0.14 ± 0.04	0.27 ± 0.09
Direct bilirubin (mg/dl)	0.16 ± 0.26	0.18 ± 0.07	0.08 ± 0.08	0.10 ± 0.08	0.24 ± 0.06	0.11 ± 0.02
Glucose (mg/dl)	137.82 ± 28.47	123.76 ± 6.28	132.53 ± 7.88	143.23 ± 6.55	153.77 ± 28.98	145.22 ± 34.38
Alkaline phosphatase (U/l)	50.47 ± 9.34	61.42 ± 4.80	56.76 ± 19.15	53.08 ± 24.68	43.95 ± 5.11	49.92 ± 2.11
AST (U/l)	26.85 ± 4.72	29.81 ± 5.67	24.33 ± 7.22	27.33 ± 5.19	32.98 ± 16.21	30.33 ± 3.05
ALT (U/l)	6.90 ± 1.36	6.99 ± 1.36	7.10 ± 1.98	7.40 ± 2.36	7.55 ± 1.70	7.89 ± 3.22