Sequence comparison of select α-Ctxs and their selectivity profiles
| Amino Acid Sequence | nAChR Potency | Reference | |
|---|---|---|---|
| α-Conotoxin | |||
| LvIA | GCCSHPACNVDHPEIC | α3β2 > α3β4; α6/α3β2β3 = α6/α3β4 | (Luo et al., 2014) |
| TxIB | GCCSDPPCRNKHPDLC | α6/α3β2β3 > >α3β2,α3β4,α6/α3β4 | (Luo et al., 2013) |
| PnIA | GCCSLPPCAANNPDYC | α3β2 > >α3β4; α6/α3β2β3 > α6/α3β4 | (Luo et al., 1999) |
| LvIA(N9R,V10A) | GCCSHPACRADHPEIC | α3β2 > >>α3β4; α6/α3β2β3 > >α6/α3β4 | This work |
>, 2- to 99-fold; > >, 100- to 500-fold; > >>, >1000-fold.
Residues shaded are conserved between the four peptides, and residues bolded are those substituted from TxIB and PnIA.