Log KD values obtained from 3H-CGP12177 whole cell binding in CHO-tβ1 and CHO-hβ2 cells
Values represent mean ± S.E.M. of n separate experiments.
| Ligand | β1AR | β2AR | ||
|---|---|---|---|---|
| Log KD | n | Log KD | n | |
| Cyanopindolol | −10.46 ± 0.04 | 6 | −10.49 ± 0.01 | 12 |
| 7-Methylcyanopindolol | −10.37 ± 0.03 | 6 | −10.42 ± 0.04 | 14 |
| Carazolol | −10.23 ± 0.04 | 5 | −10.54 ± 0.04 | 10 |
| (±)-Isoprenaline | −7.34 ± 0.11 | 5 | −6.57 ± 0.08 | 8 |
| ICI118551 | −7.17 ± 0.06 | 5 | −9.36 ± 0.07 | 10 |
| CGP20712A | −7.76 ± 0.05 | 5 | −5.76 ± 0.02 | 10 |
CGP20712A, 2-hydroxy-5-(2-[(hydroxy-3-[4-(1-methyl-4-trifluoromethyl-2-imidazolyl)phenoxy]propyl)amino]ethoxy)benzamide; CHO-tβ1, CHO cells stably expressing the turkey β1AR.