Incidence of CHB and heart rates from in vivo FTY720 and propranolol administration in WT, KI, and KO mice acutely pretreated with either vehicle or SPM-354
| Treatment Group | FTY720 + Propranolola | |||
|---|---|---|---|---|
| Vehicleb | SPM-354b | |||
| Number of Mice without CHB (Mice Tested) | Heart Rate | Number Mice without CHB (Mice Tested) | Heart Rate | |
| bpm | bpm | |||
| Wild type | 1 (9) | N.D. | 7 (8) | 219 ± 12 |
| Knockin | 2 (7) | N.D. | 4 (4) | 148 ± 7.0 |
| Knockout | 5 (5) | 350 ± 6.0 | N.D. | N.D. |