Percentages of IBa modulation by opioid receptor agonists and antagonists in Cav2.3/μ-, δ-, or κ-OR cells and Cav2.2/μ-, δ-, or κ-OR cells
DAMGO (1 μM), SNC80 (1 μM), and Sal-A (1 μM) were used as agonists, whereas naloxone (1 μM), BNTX (100 nM), and GNTI (100 nM) were used as antagonists of µ-, δ-, and κ-ORs, respectively. Inhibition and potentiation data are shown as the mean ± S.E.M. (n, number of experiments, in parentheses). Total modulation (mean) is estimated as the sum of inhibition and potentiation.
| Cell Type | Agonist | Antagonist | Total Modulation |
|---|---|---|---|
| % inhibition | % potentiation | % | |
| Cav2.3/μ-OR | 35.2 ± 1.1 (34) | −7.3 ± 3.0 (8)a | 35.2b |
| Cav2.3/δ-OR | 35.9 ± 1.6 (22) | 18.2 ± 4.7 (7) | 54.1 |
| Cav2.3/κ-OR | 31.2 ± 2.7 (27) | 23.8 ± 5.4 (6) | 55 |
| Cav2.2/μ-OR | 52.8 ± 3.8 (11) | −1.3 ± 2.4 (5) | 52.8b |
| Cav2.2/δ-OR | 60.9 ± 4.9 (9) | 77.3 ± 7.4 (6) | 138.2 |
| Cav2.2/κ-OR | 22.6 ± 4.9 (12) | 72.0 ± 8.9 (5) | 94.0 |