TABLE 1
Representative sigma-1 receptor agonists and antagonists
| Compound | Structure | Function |
|---|---|---|
| (+) Pentazocine |  | Agonist |
| (+) SKF10047 |  | Agonist |
| PRE 084 |  | Agonist |
| Dimethyl tryptamine (DMT) |  | Agonist |
| BD-1047 |  | Antagonist |
| BD-1063 |  | Antagonist |
| Rimcazole |  | Antagonist |
| NE-100 |  | Antagonist |
NE-100, N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]-ethylamine monohydrochloride; PRE-084, 2-(4-morpholinethyl) 1-phenylcyclohexane-1-carboxylate hydrochloride.