Amino acid residues of the sigma-1 receptor affected by mutation
| Amino Acid Mutation or Chemical Modification | Sigma Ligand Tested | References |
|---|---|---|
| Ser99 | [3H]-(+)-pentazocine | (Yamamoto et al., 1999) |
| Ser101 | [3H]-(+)-pentazocine | (Brune et al., 2014) |
| Tyr103 | [3H]-(+)-pentazocine | (Brune et al., 2014; Yamamoto et al., 1999) |
| Leu 105, 106 (disubstituted) | [3H]-(+)-pentazocine and [3H]-NE100 | (Yamamoto et al., 1999) |
| Phe107 | [3H]-(+)-pentazocine | (Brune et al., 2014) |
| Arg119 | [3H]-(+)-pentazocine | (Brune et al., 2014) |
| Ser125 | [3H]-(+)-pentazocine | (Brune et al., 2014) |
| Asp126 | [3H]-haloperidol and [3H]-(+)-pentazocine | (Brune et al., 2014; Seth et al., 2001) |
| Thr127 | [3H]-(+)-pentazocine | (Brune et al., 2014) |
| Ile128 | [3H]-(+)-pentazocine | (Brune et al., 2014) |
| Glu172 | [3H]-haloperidol and [3H]-(+)-pentazocine | (Brune et al., 2014; Seth et al., 2001) |
| Tyr173 | [3H]-(+)-pentazocine | (Brune et al., 2014) |
| Arg175 | [3H]-(+)-pentazocine | (Brune et al., 2014) |