Differentially expressed genes in HCC samples compared with normal liver samples
| Downregulated Genes | Adjusted P Value | Ratio | Upregulated Genes | Adjusted P Value | Ratio | Upregulated Genes | Adjusted P Value | Ratio |
|---|---|---|---|---|---|---|---|---|
| CYP2E1 | 1.98E-04 | −39 | TOP2A | 3.19E-12 | 67 | KIT | 1.42E-02 | 3 |
| CYP1A2 | 8.28E-04 | −33 | CDKN2A | 7.88E-10 | 45 | GSTA4 | 4.05E-05 | 3 |
| SLC22A1 | 5.60E-05 | −28 | MKI67 | 2.56E-09 | 29 | ACTB | 2.02E-07 | 3 |
| CYP3A4 | 1.63E-02 | −23 | SFN | 1.95E-04 | 17 | ABCB9 | 4.12E-02 | 3 |
| SLCO1B3-SLC21A8 | 7.50E-05 | −23 | BIRC5 | 1.92E-10 | 17 | C8orf33 | 2.63E-06 | 3 |
| MT1H | 2.01E-05 | −21 | E2F1 | 6.92E-12 | 15 | ABCD1 | 3.07E-05 | 3 |
| MT1X | 4.45E-09 | −19 | XRCC2 | 1.95E-07 | 11 | HSP90AA1 | 8.43E-03 | 2 |
| SLC28A1 | 3.93E-04 | −18 | CCNE1 | 6.66E-07 | 9 | NRAS | 3.45E-06 | 2 |
| CYP2C19; CYP2C8 | 2.69E-03 | −15 | SLC2A5 | 7.85E-03 | 8 | UGCG | 3.00E-04 | 2 |
| MT1A | 1.31E-05 | −15 | SLC16A3 | 1.07E-04 | 8 | CDC42 | 1.51E-06 | 2 |
| CYP2C8 | 2.81E-04 | −15 | RAD51 | 1.30E-07 | 8 | TRAF1 | 2.53E-03 | 2 |
| MT1F | 2.82E-04 | −13 | MMP9 | 2.29E-04 | 7 | CDK2 | 7.01E-03 | 2 |
| CYP2B6 | 3.23E-03 | −10 | SLC7A11 | 1.46E-02 | 7 | ATP1B1 | 5.59E-03 | 2 |
| CYP2C9 | 7.04E-03 | −10 | CHEK1 | 2.91E-05 | 7 | PDGFRB | 5.70E-03 | 2 |
| GSTM5 | 6.08E-04 | −9 | ITGAE | 2.25E-02 | 6 | SLC29A1 | 2.46E-03 | 2 |
| ABCC9 | 3.01E-08 | −8 | SLC7A5 | 1.00E-03 | 6 | UBL5 | 3.66E-05 | 2 |
| MT2A | 1.12E-03 | −6 | MSH2 | 1.23E-09 | 5 | ABCC10 | 3.09E-04 | 2 |
| SLCO4A1-SLC21A12 | 9.09E-03 | −6 | XRCC3 | 1.21E-06 | 5 | CFL1 | 4.85E-06 | 2 |
| ABCA9 | 2.71E-03 | −5 | GJA1 | 6.38E-09 | 4 | CDK4 | 3.08E-02 | 2 |
| ABCC11 | 8.18E-04 | −5 | BRCA2 | 1.09E-04 | 4 | XRCC1 | 1.22E-04 | 2 |
| SLC7A2 | 6.73E-04 | −4 | S100A10 | 3.43E-05 | 4 | COX7A2 | 1.08E-03 | 2 |
| ABCG4 | 6.47E-04 | −3 | CLDN7 | 3.31E-02 | 4 | BAX | 2.51E-04 | 2 |
| ABCA1 | 1.14E-02 | −2 | TGFB1 | 2.94E-04 | 3 | HSF1 | 5.28E-04 | 2 |
| STAT3 | 7.49E-05 | −2 | LBR | 4.76E-07 | 3 | SIRT7 | 1.27E-04 | 2 |
| 18S | 3.89E-08 | −2 | SLC1A5 | 2.32E-02 | 3 | MSH6 | 2.82E-05 | 2 |
| SEPX1 | 1.71E-03 | −2 | CHEK2 | 4.17E-04 | 3 | ABCF2 | 1.06E-03 | 2 |
| PDCD8/AIFM1 | 3.85E-03 | −2 | ABCC4 | 1.10E-02 | 3 | ABCC5 | 1.35E-02 | 2 |
| SLC31A1 | 1.36E-04 | −2 | TXN | 4.55E-10 | 3 | CTNNB1 | 3.48E-03 | 2 |
| AKT1 | 4.92E-02 | −2 | SRC | 4.41E-03 | 3 | GPX4 | 2.63E-02 | 2 |
| NR1H3 | 4.75E-02 | −2 | RAD18 | 3.94E-09 | 3 | RAD1 | 1.46E-02 | 2 |
| CFLAR | 1.46E-02 | −1.5 | HSPB1 | 8.50E-06 | 3 | ABCB10 | 3.02E-04 | 2 |
| ERCC6;PGBD3 | 1.53E-02 | −1.4 | BAK1 | 6.55E-07 | 3 | FKBP1A | 5.09E-04 | 2 |
| TP53BP2 | 3.37E-08 | 3 | ERCC2 | 4.33E-02 | 2 | |||
| ABCC1 | 6.04E-03 | 3 | XRCC6 | 3.04E-02 | 2 | |||
| ATOX1 | 8.52E-05 | 3 | APEX1 | 3.75E-02 | 2 | |||
| POLH | 4.75E-02 | 1.4 |