TABLE 1

Effect of 1 μM isoproterenol on the voltage dependence of endogenous Kv7.5 and exogenous homomeric hKv7.4, homomeric hKv7.5, and heteromeric hKv7.4/7.5 channels

Kv7 isoform	G_max ISO/G_max Control x 100%	V_0.5		k
Kv7 isoform	G_max ISO/G_max Control x 100%	Control	1 μM ISO	Control	1 μM ISO
	%	mV	mV	mV	mV
Endogenous Kv7.5, n = 10	259.3 ± 33.8^{^a}	−48.5 ± 2.5	−47.8 ± 2.7	9.5 ± 1.0	11.3 ± 0.8
Exogenous hKv7.5, n = 5	267.4 ± 16.6^{^b}	−46.2 ± 2.5	−46.1 ± 2.1	12.3 ± 0.8	13.6 ± 1.7
Exogenous hKv7.4, n = 5	98.1 ± 3.1	−28.6 ± 2.0	−28.2 ± 1.6	10.8 ± 0.7	10.7 ± 0.7
Exogenous hKv7.4/7.5, n = 5	134.9 ± 9.3^{^a}	−34.0 ± 3.9	−35.5 ± 5.6	11.3 ± 0.8	12.1 ± 0.9

G_max, maximal conductance; ISO, isoproterenol; k, slope factor; V_0.5, voltage of half-maximal activation.
↵^a Significantly different from control, paired Student’s t test, P < 0.05.
↵^b Significantly different from control, paired Student’s t test, P < 0.001.