Effects of the stereoisomers on the saturation binding of [3H]-dopamine to the human dopamine D2 receptor
Data are mean ± standard deviation from three separate experiments.
| Control | + R Isomer (10 μM) | + S Isomer (10 μM) | |
|---|---|---|---|
| Kd (nM) | 15 ± 3 | 13 ± 3 | 17 ± 6 |
| Bmax (% control) | 100 ± 6 | 137 ± 10* | 82 ± 15 |
↵* P < 0.05, Student’s paired t test.