TABLE 3 

(Continued from Table 2: CREB and PLCβ3 Responses)

CREB Response (Gαs)PLCβ3 Response (Gαq)
logR (τ/KA)ΔlogR (τ/KA)alogR (τ/KA)ΔlogR (τ/KA)a
WINSTHdhQ7/Q73.43(3.32–3.54)†Reference ligand6.54(6.32–6.72)Reference ligand
STHdhQ111/Q1112.22(2.20–2.24)^†Reference ligand6.51(6.34–6.66)Reference ligand
CPSTHdhQ7/Q76.47(6.46–6.48)*3.01(2.91–3.11)*†5.77(5. 67–5.87)*†−0.77(–0.92–0.62)*†
STHdhQ111/Q1115.07(5.06–5.08)*2.85(2.55–3.04)*†6.32(4.35–8.29)^−0.21(–0.48–0.06)^
2-AGSTHdhQ7/Q7N.C.N.C.6.01(4.66–7.36)−0.53(–0.88–0.18)*†
STHdhQ111/Q111N.C.N.C.5.76(4.99–6.53)−0.71(–1.46–0.04)
AEASTHdhQ7/Q7N.C.N.C.6.31(6.08–6.54)−0.23(–0.47–0.01)
STHdhQ111/Q111N.C.N.C.5.41(4.52–5.94)*^†−1.13(–1.99–0.27)*†
THCSTHdhQ7/Q7N.C.N.C.5.45(5.23–5.67)*†−1.09(–1.31–0.87)*
STHdhQ111/Q111N.C.N.C.4.33(3.80–4.86)*^†−2.18(–2.69–1.67)*^
CBDSTHdhQ7/Q73.34(3.29–3.39)−0.09(–0.22–0.04)N.C.N.C.
STHdhQ111/Q1112.27(2.24–2.30)0.03(–0.01–0.07)N.C.N.C.
THC + CBDSTHdhQ7/Q70.26(–0.40–1.92)*−3.19(–3.21–3.17)*0.57(–1.43–1.91)*−5.97(–6.20–5.74)*
STHdhQ111/Q1113.28(3.27–3.30)*†1.06(1.04–1.08)*^†4.25(3.55–4.95)*^−2.27(–2.95–1.59)*^