Comparison of potencies of CRTh2 antagonists QAV680 and QAW039 for inhibition of PGD2-induced cytokine release in human CD4+ Th2 lymphocytes
Data are mean ± S.E.M. from at least three separate experiments.
| CRTh2 Antagonist | Inhibition of IL-5 Release IC50 | Inhibition of IL-13 Release IC50 |
|---|---|---|
| nM | nM | |
| QAW039 | 2.56 ± 1.24 | 1.40 ± 0.30 |
| QAV680 | 57 ± 28 | 29 ± 5 |