Compound | Parameter | pERK1/2 | cAMP | pAkt | Ca2+i | Survival |
---|---|---|---|---|---|---|
IB-MECA | Log (τ/KA) | 9.5 ± 0.3 | 9.4 ± 0.1 | 9.4 ± 0.3 | 8.6 ± 0.2 | 9.6 ± 0.2 |
ΔLog (τ/KA) | 0 | 0 | 0 | 0 | 0 | |
Log (bias factor) | 0 | 0 | 0 | 0 | 0 | |
Bias factor | 1 | 1 | 1 | 1 | 1 | |
NECA | Log (τ/KA) | 8.6 ± 0.1 | 8.5 ± 0.2 | 8.1 ± 0.3 | 8.2 ± 0.1 | 8.4 ± 0.1 |
ΔLog(τ/KA) | −0.9 ± 0.3 | −0.9 ± 0.1 | −1.3 ± 0.3 | −0.4 ± 0.2 | −1.2 ± 0.3 | |
Log (bias factor) | 0 | 0.1 ± 0.2 | −0.4 ± 0.2 | 0.6 ± 0.3 | −0.3 ± 0.3 | |
Bias factor | 1 | 1.0 | 0.4 | 3.6 | 0.5 | |
HEMADO | Log (τ/KA) | 9.4 ± 0.1 | 8.8 ± 0.2 | 8.9 ± 0.1 | 8.7 ± 0.2 | 9.2 ± 0.1 |
ΔLog (τ/KA) | −0.1 ± 0.2 | −0.6 ± 0.2 | −0.4 ± 0.3 | 0.1 ± 0.1 | −0.4 ± 0.2 | |
Log (bias factor) | 0 | −0.5 ± 0.4 | −0.3 ± 0.2 | 0.2 ± 0.2 | −0.3 ± 0.2 | |
Bias factor | 1 | 0.3 | 0.5 | 1.7 | 0.5 | |
AB-MECA | Log (τ/KA) | 8.0 ± 0.1 | 7.7 ± 0.2 | 8.0 ± 0.3 | 7.5 ± 0.2 | 7.7 ± 0.3 |
ΔLog (τ/KA) | −1.5 ± 0.3 | −1.7 ± 0.2 | −1.4 ± 0.1 | −1.1 ± 0.1 | −1.9 ± 0.6 | |
Log (bias factor) | 0 | −0.2 ± 0.4 | 0.1 ± 0.2 | 0.4 ± 0.3 | −0.4 ± 0.6 | |
Bias factor | 1 | 0.6 | 1.2 | 2.5 | 0.4 | |
MRS3558 | Log (τ/KA) | 9.7 ± 0.2 | 9.7 ± 0.1 | 9.4 ± 0.2 | 8.4 ± 0.2 | 10.3 ± 0.3 |
ΔLog (τ/KA) | 0.2 ± 0.2 | 0.3 ± 0.1 | −0.1 ± 0.2 | −0.2 ± 0.1 | 0.7 ± 0.4 | |
Log (bias factor) | 0 | 0.1 ± 0.1 | −0.2 ± 0.3 | −0.4 ± 0.2 | 0.5 ± 0.3 | |
Bias factor | 1 | 1.4 | 0.6 | 0.4 | 3.1 | |
MRS5655 | Log (τ/KA) | 9.0 ± 0.4 | 9.1 ± 0.1 | 8.9 ± 0.4 | 7.4 ± 0.3 | 9.9 ± 0.2 |
ΔLog (τ/KA) | −0.6 ± 0.1 | −0.2 ± 0.1 | −0.5 ± 0.3 | −1.1 ± 0.2 | 0.3 ± 0.4 | |
Log (bias factor) | 0 | 0.3 ± 0.1 | 0.1 ± 0.2 | −0.6 ± 0.2 | 0.9 ± 0.4 | |
Bias factor | 1 | 2.1 | 1.1 | 0.3 | 8.1 | |
MRS5667 | Log (τ/KA) | 8.2 ± 0.1 | 8.7 ± 0.1 | 8.2 ± 0.1 | 7.6 ± 0.1 | 9.8 ± 0.1 |
ΔLog (τ/KA) | −1.3 ± 0.1 | −0.6 ± 0.1 | −1.2 ± 0.1 | −1.0 ± 0.1 | 0.2 ± 0.1 | |
Log (bias factor) | 0 | 0.7 ± 0.2 | 0.2 ± 0.1 | 0.3 ± 0.2 | 1.6 ± 0.1 | |
Bias factor | 1 | 4.7 | 1.4 | 2.0 | 36 | |
MRS5679 | Log (τ/KA) | 7.3 ± 0.3 | 7.6 ± 0.3 | 7.0 ± 0.3 | 5.9 ± 0.4 | 9.7 ± 0.2 |
ΔLog (τ/KA) | −2.3 ± 0.1 | −1.7 ± 0.3 | −2.4 ± 0.1 | −2.7 ± 0.2 | 0.1 ± 0.1 | |
Log (bias factor) | 0 | 0.5 ± 0.4 | −0.2 ± 0.2 | −0.5 ± 0.3 | 2.3 ± 0.1 | |
Bias factor | 1 | 3.2 | 0.7 | 0.4 | 224 | |
MRS5698 | Log (τ/KA) | 8.1 ± 0.1 | 8.5 ± 0.2 | 8.1 ± 0.1 | 7.8 ± 0.1 | 9.4 ± 0.1 |
ΔLog (τ/KA) | −1.4 ± 0.1 | −0.9 ± 0.2 | −1.2 ± 0.1 | −0.7 ± 0.1 | −0.1 ± 0.1 | |
Log (bias factor) | 0 | 0.5 ± 0.3 | 0.2 ± 0.1 | 0.7 ± 0.2 | 1.3 ± 0.1 | |
Bias factor | 1 | 3.2 | 1.6 | 5.0 | 20 | |
MRS5704 | Log (τ/KA) | 6.2 ± 0.1 | 6.5 ± 0.1 | 6.0 ± 0.1 | 5.3 ± 0.2 | 7.9 ± 0.4 |
ΔLog (τ/KA) | −3.3 ± 0.1 | −2.9 ± 0.1 | −3.3 ± 0.1 | −3.3 ± 0.2 | −1.7 ± 0.4 | |
Log (bias factor) | 0 | 0.4 ± 0.1 | −0.1 ± 0.1 | 0.1 ± 0.2 | 1.6 ± 0.3 | |
Bias factor | 1 | 2.6 | 0.9 | 1.0 | 44 | |
MRS5783 | Log (τ/KA) | 6.1 ± 0.1 | 6.4 ± 0.2 | 5.9 ± 0.1 | 5.5 ± 0.1 | 7.8 ± 0.4 |
ΔLog (τ/KA) | −3.4 ± 0.1 | −2.9 ± 0.2 | −3.5 ± 0.1 | −3.1 ± 0.1 | −1.8 ± 0.4 | |
Log (bias factor) | 0 | 0.5 ± 0.1 | −0.1 ± 0.1 | 0.3 ± 0.1 | 1.6 ± 0.4 | |
Bias factor | 1 | 3.0 | 0.8 | 2.0 | 43 | |
MRS5857 | Log (τ/KA) | 9.4 ± 0.5 | 9.1 ± 0.1 | 9.3 ± 0.5 | 7.6 ± 0.3 | 10.2 ± 0.2 |
ΔLog (τ/KA) | −0.1 ± 0.2 | −0.3 ± 0.2 | −0.1 ± 0.2 | −1.0 ± 0.2 | 0.6 ± 0.3 | |
Log (bias factor) | 0 | −0.2 ± 0.3 | 0.1 ± 0.1 | −0.8 ± 0.4 | 0.8 ± 0.3 | |
Bias factor | 1 | 0.7 | 1.1 | 0.2 | 5.9 | |
MRS5916 | Log (τ/KA) | 9.5 ± 0.1 | 9.5 ± 0.1 | 9.2 ± 0.1 | 8.2 ± 0.1 | 9.7 ± 0.1 |
ΔLog (τ/KA) | −0.1 ± 0.1 | 0.1 ± 0.1 | −0.1 ± 0.1 | −0.3 ± 0.1 | 0.1 ± 0.1 | |
Log (bias factor) | 0 | 0.1 ± 0.2 | −0.1 ± 0.1 | −0.3 ± 0.1 | 0.1 ± 0.1 | |
Bias factor | 1 | 1.3 | 0.8 | 0.5 | 1.3 | |
MRS7030 | Log (τ/KA) | 8.2 ± 0.1 | 8.8 ± 0.2 | 8.1 ± 0.1 | 7.2 ± 0.1 | 9.0 ± 0.1 |
ΔLog(τ/KA) | −1.3 ± 0.1 | −0.5 ± 0.2 | −1.3 ± 0.1 | −1.4 ± 0.1 | −0.6 ± 0.1 | |
Log (bias factor) | 0 | 0.8 ± 0.2 | 0.1 ± 0.1 | −0.1 ± 0.1 | 0.8 ± 0.2 | |
Bias factor | 1 | 6.3 | 1.2 | 1.0 | 6.2 | |
MRS7034 | Log (τ/KA) | 8.1 ± 0.2 | 9.4 ± 0.1 | 8.1 ± 0.2 | 7.5 ± 0.1 | 9.7 ± 0.1 |
ΔLog (τ/KA) | −1.4 ± 0.2 | 0.1 ± 0.1 | −1.3 ± 0.2 | −1.0 ± 0.1 | 0.1 ± 0.1 | |
Log (bias factor) | 0 | 1.4 ± 0.2 | 0.1 ± 0.1 | 0.3 ± 0.3 | 1.4 ± 0.1 | |
Bias factor | 1 | 23.4 | 1.3 | 2.1 | 28 |
Significance as illustrated in Fig. 4.