TABLE 3

Comparison of experimentally and model-derived first-order association rate-constants for binding of cisapride to K_V11.1 at 22–37°C

	k_on · [cisapride] (s⁻¹)
	10 nM		20 nM		60 nM		200 nM		600 nM
	Experiment	Model	Experiment	Model	Experiment	Model	Experiment	Model	Experiment	Model
22°C	0.010 ± 0.002	0.010	0.025 ± 0.002	0.020	0.098 ± 0.02	0.060	0.167 ± 0.02	0.191	0.452 ± 0.06	0.486
27°C	0.029 ± 0.007	0.022	0.060 ± 0.010	0.044	0.138 ± 0.02	0.128	0.463 ± 0.04	0.386	0.878 ± 0.11	0.865
32°C	0.054 ± 0.008	0.047	0.111 ± 0.019	0.092	0.219 ± 0.02	0.265	0.796 ± 0.09	0.737	1.195 ± 0.14	1.45
37°C	0.092 ± 0.011	0.096	0.137 ± 0.022	0.188	0.254 ± 0.05	0.518	0.915 ± 0.01	1.27	1.065 ± 0.13	2.14