Antiviral activities from viral cytopathic assay of selected derivatives of acylguanidine against S31 and N31 forms of the A/PR/8/1934(H1N1) V27 influenza virus
| Compound | Viral Cytopathic Assay | |
|---|---|---|
| Estimated EC50 (µM) | ||
| A/PR/8/1934(H1N1) V27 | ||
| S31 | N31 | |
| Amantadine | <1 | >100 |
| M2WJ352 | 34 ± 6 | 1.8 ± 0.7 |
| 9 | 2.3 ± 0.1 | 23 ± 5 |
| 26 | 6.9 ± 1.6 | 1.5 ± 0.1 |
| 27 | 40 ± 1 | 18 ± 1 |