TABLE 1

Sixty-second application of ATP in P2X7 chimeras

Chimera10–90% Rise TimeDecay Time ConstantI1I2n
msmspA/pFpA/pF
X7-X7-X732 ± 3252 ± 27−102 ± 31−213 ± 568
X2-X7-X738 ± 6833 ± 200−247 ± 38−425 ± 30*6
X7-X7-X281 ± 15**945 ± 204−11 ± 4−9 ± 3*5
X2-X7-X244 ± 5187 ± 24−333 ± 126−124 ± 426
X7[Δ18]54 ± 51439 ± 603**−124 ± 37−95 ± 405
X2-X2-X297 ± 7**121 ± 22−1212 ± 299**−195 ± 964
  • Values are mean ± S.E.M.

  • I1, initial peak current; I2, inward current at 60 sec; nd, not determined; n, number of experiments.

  • * P < 0.05, **P < 0.01 versus wild-type P2X7 (Tukey’s test).