Chimera | I1(pA/pF) | I2(pA/pF) | I1/Icontrol | I2/Icontrol | n |
---|---|---|---|---|---|
X7-X7-X7 | −110 ± 24 | −239 ± 43 | 0.9 ± 0.0 | 2.4 ± 0.4 | 14 |
+ geldanamycin | −198 ± 45 | −253 ± 65 | 2.1 ± 0.5* | 2.5 ± 0.4 | 11 |
X2-X7-X7 | −474 ± 194 | −650 ± 232 | 0.7 ± 0.1 | 1.0 ± 0.1 | 5 |
+ geldanamycin | −427 ± 121 | −557 ± 117 | 1.0 ± 0.1 | 1.4 ± 0.2 | 5 |
X7-X7-X2 | −2 ± 1 | −1 ± 1 | 0.8 ± 0.4 | 0.4 ± 0.2 | 3 |
+ geldanamycin | −5 ± 2 | −4 ± 1 | 1.1 ± 0.0 | 0.7 ± 0.1 | 3 |
X2-X7-X2 | −74 ± 34 | −18 ± 8 | 0.5 ± 0.2 | 0.1 ± 0.0 | 6 |
+ geldanamycin | −273 ± 108 | −56 ± 17 | 0.5 ± 0.1 | 0.1 ± 0.0 | 3 |
X7[Δ18] | −101 ± 25 | −78 ± 26 | 0.8 ± 0.1 | 0.6 ± 0.1 | 8 |
+ geldanamycin | −278 ± 89 | −188 ± 66 | 0.7 ± 0.1 | 0.5 ± 0.1 | 4 |
↵* P < 0.05, **P < 0.01 versus Normal solution (Student’s t test).