TABLE 4

ATP pharmacology of P2X7 chimeras

Values are mean ± S.E.M.

ChimeraEC50(μM)Hill coefficientn
X7-X7-X71473 ± 401.712
X7-X7-X7 (geld)1377 ± 2535.47
X2-X7-X7574 ± 22**1.96
X7-X7-X2304 ± 90**0.95
X2-X7-X2543 ± 40**2.06
X7[Δ18]265 ± 51**0.95
X7[Δ18] (geld)480 ± 197**1.18
X2-X2-X213 ± 0**3.47
  • geld, geldanamycin; n, number of experiments.

  • ** P < 0.01 versus wild-type P2X7 (Tukey’s test).